X Lab Series · Preparation process

Natural killer and cytokine-induced killer cells,for immune cell therapy.

NK (natural killer) and CIK (cytokine-induced killer) cells are immune effector cells used in cancer immunotherapy. CellAuto prepares them on a closed, automated line, from apheresis to a released product ready for reinfusion.

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Overview

01

What they are

NK and CIK cells are immune effector cells that recognise and kill abnormal cells. They are used as cellular immunotherapies, often alongside other cancer treatments.

02

Why automate it

Immune-cell preparation involves isolation, activation and a period of expansion, all of which are sensitive to handling. A closed automated line keeps the process sterile and reproducible.

03

Where it is used

Cancer immunotherapy and adjuvant treatment, in both clinical research and scaled production.

The automated process

ApheresisMononuclear cells are collected from the donor by apheresis.
PBMC isolationPeripheral blood mononuclear cells (PBMCs) are isolated.
Cell sorting (optional)Target cells are sorted where the protocol requires it.
Induction and activationNK / CIK cells are induced and activated.
Transduction and expansionThe cells are transduced where required and expanded to the target quantity.
DispensingThe product is dispensed into its final containers in a closed system.
Release and reinfusionAfter passing quality-control testing, the product is released for reinfusion.

The steps above follow CellAuto’s standard automated NK / CIK workflow. Activation and expansion protocols are configured and validated for each specific product and site.

Core platform systems

Multifunctional cell processing system 
Cell sorting system 
WAVE bioreactor 
Fully-automatic dispensing system 

Every transfer between steps is made through a closed, aseptic connection, so the cells stay in a sealed path from start to finish. The exact configuration is agreed during project planning.

The rest of thepreparation processes.

MSCMesenchymal stem cells iPSCInduced pluripotent stem cells CAR-TChimeric antigen receptor T cells DCDendritic cells Clinical deliveryRecovery, washing, dispensing & release SoftwareCell Full Lifecycle Management Platform 

Bring this processonto an automated line.

Tell us the cell type, the batch size and the facility, and we will tell you what the automated preparation looks like for you.

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