\n \u2014\u2014\u6839\u636e\u5218\u6c90\u82b8\u535a\u58eb\u5728\u201c2021\u5e74\u5e7f\u4e1c\u7701\u5e72\u7ec6\u80de\u4e34\u5e8a\u7814\u7a76\u7ba1\u7406\u5de5\u4f5c\u4f1a\u8bae\u201d\u4e0a\u7684\u53d1\u8a00\u6574\u7406<\/span>\n <\/section>\n

\n
\n <\/p>\n <\/section>\n

\n \u4eca\u5929\u4f1a\u8bae\u7684\u4e3b\u9898\u662f\u201c2021\u5e74\u5e7f\u4e1c\u7701\u5e72\uff08\u4f53\uff09\u7ec6\u80de\u4e34\u5e8a\u7814\u7a76\u7ba1\u7406\u5de5\u4f5c\u4f1a\u8bae\u201d\u3002\u76ee\u524d\uff0c\u5168\u56fd\u5907\u6848\u53ef\u4ee5\u5b9e\u65bd\u5e72\u7ec6\u80de\u4e34\u5e8a\u7814\u7a76\u7684\u533b\u9662\u6709140\u5bb6\uff0c\u5176\u4e2d\u5e7f\u4e1c\u670916\u5bb6\u533b\u9662\uff0c\u83b7\u6279\u5907\u6848\u7684\u5e72\u7ec6\u80de\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u6709118\u9879\uff0c\u5728\u5e7f\u4e1c\u5f00\u5c55\u7684\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u670922\u9879\u3002<\/span>\n <\/section>\n

\n
\n <\/section>\n

\n \u4f9d\u636e\u6211\u56fd\u73b0\u884c\u7684\u5e72\u7ec6\u80de\u6cbb\u7597\u4e34\u5e8a\u8f6c\u5316\u7684\u6cd5\u5f8b\u6cd5\u89c4\uff0c\u8fd9\u4e9b\u5907\u6848\u7684\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u7ed3\u675f\u540e\u5e76\u4e0d\u662f\u5fc5\u7136\u8fdb\u5165\u4e34\u5e8a\u6210\u4e3a\u5e38\u89c4\u6cbb\u7597\u836f\u7269\uff0c\u5728\u5907\u6848\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u7ed3\u675f\u540e\u9700\u5411\u56fd\u5bb6\u836f\u76d1\u5c40\u63d0\u4ea4\u5e72\u7ec6\u80de\u65b0\u836f\u7533\u8bf7\uff0c\u90a3\u6211\u4eec\u76ee\u524d\u6b63\u5728\u5168\u56fd\u8303\u56f4\u5185\u5f00\u5c55\u7684118\u5bb6\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u80fd\u5426\u6210\u4e3a\u836f\u76d1\u5c40\u91c7\u7eb3\u7684\u4e34\u5e8a\u7814\u7a76\u6570\u636e\u5c31\u975e\u5e38\u91cd\u8981\u3002<\/span>\n <\/section>\n

\n
\n <\/section>\n

\n \u56e0\u6b64\uff0c\u76ee\u524d\u5907\u6848\u7684\u4e0a\u767e\u9879\u4e34\u5e8a\u7814\u7a76\u8be5\u5982\u4f55\u5f00\u5c55\uff1f\u7ec6\u80de\u751f\u4ea7\u8fc7\u7a0b\u5982\u4f55\u4e0e\u4e34\u5e8a\u7814\u7a76\u6cbb\u7597\u6548\u679c\u76f8\u4e92\u4fc3\u8fdb\u4e14\u76f8\u4e92\u5370\u8bc1\uff1f\u8fd9\u4e9b\u4e34\u5e8a\u7814\u7a76\u80fd\u5426\u6ee1\u8db3\u836f\u76d1\u5c40\u7684\u8bc4\u4ef7\u6807\u51c6\uff1f<\/span>\n <\/section>\n

\n
\n <\/section>\n

\n $\"\u56fe\u7247\"$ \n <\/section>\n

\n
\n <\/section>\n

\n \u6211\u4eec\u5148\u7b80\u5355\u56de\u987e\u4e00\u4e0b\u56fd\u5185\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u53d1\u5c55\u60c5\u51b5\uff1a\u4e2a\u4f53\u5316\u7684Car-T\u7ec6\u80de\u4ea7\u54c1\u5728\u4e16\u754c\u5404\u5730\u90fd\u5148\u540e\u83b7\u6279\u4e0a\u5e02\uff0c\u4eca\u5e74\u5728\u6211\u56fd\u4e5f\u5148\u540e\u67092\u4e2a\u4ea7\u54c1\u83b7\u6279\u4e0a\u5e02\uff0c\u5c3d\u7ba1MSCs\u53ef\u4ee5\u5b9e\u73b0\u5927\u89c4\u6a21\u751f\u4ea7\uff0c\u4e14\u5728\u6709\u4e9b\u56fd\u5bb6\u5df2\u83b7\u6279\u4e0a\u5e02\uff0c\u4f46\u5176\u5b9e\u9645\u5e94\u7528\u7684\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u5374\u4e0d\u4e00\u81f4\u3002\u56e0\u6b64\uff0cMSCs\u5728\u6211\u56fd\u4ecd\u662f\u4ee5\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u5907\u6848\u7684\u5f62\u5f0f\u63a8\u8fdb\u3002<\/span>\n <\/section>\n

\n
\n <\/section>\n

\n \u4eceCar-T\u4ea7\u54c1\u7684\u83b7\u6279\u4e0a\u5e02\u53ef\u4ee5\u770b\u5230\uff0c\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u80fd\u5426\u83b7\u6279\u4e0a\u5e02\uff0c\u5176\u6839\u672c\u5728\u4e8e\u4e34\u5e8a\u7597\u6548\u3002Car-T\u81ea2011\u5e747\u6708\u5728\u201c\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u201d\u4e0a\u62a5\u9053\u4e2a\u6848\u6cbb\u7597\u75c5\u4f8b\u2014\u2014Emily Whitehead\u540e\uff0c\u4e34\u5e8a\u7597\u6548\u4e0d\u4ec5\u6e05\u6670\u660e\u786e\uff0c\u800c\u4e14\u7597\u6548\u6301\u7eed\u81f3\u4eca\u3002<\/span>\n <\/section>\n

\n
\n <\/section>\n

\n \u76f8\u6bd4\u4e8eCar-T\u7684\u4e34\u5e8a\u7597\u6548\uff0cMSCs\u867d\u7136\u5e94\u7528\u975e\u5e38\u5e7f\u6cdb\uff0c\u4f46\u5374\u6ca1\u6709\u8868\u73b0\u51faCar-T\u4e00\u822c\u795e\u5947\u7684\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u3002<\/span>\n <\/section>\n

\n
\n <\/section>\n

\n Car-T\u7684\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u4e0d\u4ec5\u662f\u4ece\u6bcf\u4e2a\u53c2\u4e0e\u4e34\u5e8a\u7814\u7a76\u7684\u5177\u4f53\u75c5\u4f8b\u4e2d\u8868\u73b0\u51fa\u6765\uff0c\u800c\u4e14\u90fd\u80fd\u901a\u8fc7\u5176\u4ea7\u54c1\u8bbe\u8ba1\u4e0e\u4ea7\u54c1\u63cf\u8ff0\u5f97\u5230\u4f53\u73b0\uff0c\u5c06\u53cd\u5e94\u5176\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u7684\u5173\u952e\u8d28\u91cf\u5c5e\u6027\uff08CQA\uff09\u5d4c\u5165\u5230\u5173\u952e\u5de5\u827a\u53c2\u6570\uff08CPP\uff09\u4e2d\uff0c\u5e76\u5f62\u6210\u5176\u56fa\u5316\u7684\u751f\u4ea7\u5de5\u827a\u3002\u4e5f\u5c31\u662f\u8bf4\uff0cCar-T\u4ea7\u54c1\u4ece\u5f00\u53d1\u7684\u65f6\u5019\u5c31\u662f\u56f4\u7ed5\u7740\u6cbb\u7597\u67d0\u4e00\u79cd\u75be\u75c5\u5f00\u5c55\u7684\u3002\u4f46MSCs\u4f3c\u4e4e\u4e0d\u662f\uff0cMSCs\u4ea7\u54c1\u7684CQA\u548cCPP\u7684\u76ee\u6807\u662f\u56f4\u7ed5\u7740\u5982\u4f55\u83b7\u5f97\u8db3\u591f\u91cf\u7684MSCs\uff0c\u5e76\u4e0d\u662f\u56f4\u7ed5\u7740MSCs\u7528\u4e8e\u6cbb\u7597\u67d0\u4e00\u79cd\u7279\u5b9a\u75be\u75c5\u8fdb\u884c\u3002<\/span>\n <\/section>\n

\n
\n <\/section>\n

\n \u4ece\u56fd\u9645\u3001\u56fd\u5185\u7684MSCs\u6ce8\u518c\u3001\u5907\u6848\u7684\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u6765\u770b\uff0cMSCs\u7684\u4e34\u5e8a\u7528\u9014\u975e\u5e38\u5e7f\u6cdb\uff0c\u5728NIH\u7684Clinicaltrial.gov\u7f51\u7ad9\u4e0a\u4ee5\u201cMSC\u201d\u4f5c\u4e3a\u5173\u952e\u8bcd\u641c\u7d22\u5230\u7684\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u9ad8\u8fbe10900\u591a\u9879\uff0c\u56fd\u5bb6\u536b\u5065\u59d4\u5907\u6848\u7684\u5e72\u7ec6\u80de\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u4e2dMSCs\u7684\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u670974\u9879\uff0c\u76ee\u524d\u56fd\u5bb6\u836f\u76d1\u5c40\u7684CDE\u53d7\u7406\u7684MSCs\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u8fbe19\u9879\uff0c\u6d89\u53ca\u7684\u9002\u5e94\u75c7\u6709\u4e0a\u767e\u79cd\u3002 <\/span>\n <\/section>\n

\n
\n <\/section>\n

\n \u4f46\u81f3\u4eca\uff0c\u5728\u6211\u56fd\u6ca1\u6709\u4e00\u4e2aMSCs\u83b7\u6279\u4e0a\u5e02\uff0cCDE\u53d7\u7406\u7684MSCs\u4ea7\u54c1\u7533\u62a5\u4e2d\uff0c\u5c1a\u672a\u6709\u63f4\u5f15\u5907\u6848\u4e34\u5e8a\u7814\u7a76\u4f5c\u4e3a\u201c\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\u201d\u652f\u6301\u7ec6\u80de\u836f\u7269\u7684\u5ba1\u8bc4\u5ba1\u6279\u3002\u90a3\u73b0\u5728\u6b63\u5728\u5f00\u5c55\u3001\u8fd8\u6709\u4e0d\u65ad\u5907\u6848\u7684MSCs\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u5982\u4f55\u624d\u80fd\u5f62\u6210\u5bf9\u540e\u7eed\u7684\u65b0\u836f\u7533\u62a5\u53d1\u6325\u57fa\u7840\u6027\u3001\u7d2f\u79ef\u6027\u7684\u6570\u636e\u652f\u6301\uff1f<\/span>\n <\/section>\n

\n
\n <\/section>\n

\n \u7ec6\u80de\u836f\u7269\u7684CQA\u4e0e\u4e34\u5e8a\u6cbb\u7597\u9002\u5e94\u75c7\u606f\u606f\u76f8\u5173\uff0c\u800c\u5176CQA\u7684\u7a33\u5b9a\u6027\u9700\u8981\u7528CPP\u4e88\u4ee5\u754c\u5b9a\u3002\u901a\u5e38\u6709\u5982\u4e0b\u51e0\u4e2a\u7ef4\u5ea6\u3002<\/span><\/strong><\/span>\n <\/section>\n
\n
\n
\n
\n
\n
\n
\n <\/section>\n <\/section>\n
\n
\n
\n
\n 0<\/strong>1<\/strong><\/span>\n <\/section>\n <\/section>\n
\n
\n \u9274\u5b9a\u6027\u6307\u6807\uff08Identity\uff09<\/strong><\/span>\n <\/section>\n
\n
\n \u901a\u5e38\u662f\u8868\u660e\u7ec6\u80de\u8eab\u4efd\u6216\u7c7b\u578b\u7684\u8868\u578b\u548c\u5f62\u6001\u5b66\u6307\u6807\u3002\u6709\u7ec6\u957f\u68ad\u578b\uff0c\u4e5f\u6709\u80a5\u80d6\u578b\u7b49\u3002<\/span>\n <\/p>\n <\/section>\n <\/section>\n <\/section>\n
\n
\n
\n 0<\/strong>2<\/strong><\/span>\n <\/section>\n <\/section>\n
\n
\n \u6d3b\u6027\u6307\u6807\uff08Viability\uff09<\/strong><\/span>\n <\/section>\n
\n
\n \u8868\u660e\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u662f\u5904\u4e8e\u751f\u673a\u52c3\u53d1\u7684\u201c\u9752\u58ee\u5e74\u201d\u8fd8\u662f\u5904\u4e8e\u8870\u9000\u671f\u7684\u201c\u4e2d\u8001\u5e74\u201d\u3002\u5982\u524d\u6240\u8ff0\uff0c\u6700\u4f73\u72b6\u6001\u7684MSCs\u7684\u5f62\u6001\u4e3a\u7ec6\u957f\u68ad\u578b\uff0c\u4f46\u662f\u8870\u8001\u7684MSCs\u5448\u73b0\u7684\u5f62\u6001\u662f\u80a5\u80d6\u7684\u7b49\u3002\u7406\u8bba\u4e0a\u6765\u8bb2\uff0c\u4e00\u822c\u6700\u4f73\u72b6\u6001\u8981\u6c42\u8be5\u6307\u6807\u8fbe\u523070%-80%\u4ee5\u4e0a\uff0c\u4f46\u76ee\u524d\u5e38\u7528\u7684MSCs\u4ea7\u54c1\u8bc4\u4ef7\u6307\u6807\u65e0\u6cd5\u786e\u5207\u7684\u5bf9\u201c\u6700\u4f73\u72b6\u6001\u201d\u548c\u201c\u8870\u8001\u72b6\u6001\u201d\u52a0\u4ee5\u533a\u5206\u3002<\/span>\n <\/p>\n <\/section>\n <\/section>\n <\/section>\n
\n
\n
\n 0<\/strong>3<\/strong><\/span>\n <\/section>\n <\/section>\n
\n
\n \u6f5c\u80fd\u6307\u6807\uff08Potency-Ability of Cells to Perform Desired Action\uff09<\/strong><\/span>\n <\/section>\n
\n
\n \u8868\u660e\u8be5\u7c7b\u578b\u7684\u7ec6\u80de\u5177\u6709\u4ec0\u4e48\u6837\u7684\u7ec6\u80de\u529f\u80fd\uff0c\u8fd9\u79cd\u7ec6\u80de\u529f\u80fd\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597\u4ec0\u4e48\u75be\u75c5\u3002\u4ece\u76f8\u5173\u7814\u7a76\u4e2d\u53ef\u4ee5\u770b\u51fa\uff0cCar-T\u7684potency\u8bc4\u4ef7\u6307\u6807\u662f\u5176\u6297\u80bf\u7624\u80fd\u529b\u3002\u4f46\u4ece\u4e34\u5e8a\u4e2d\u7528\u4e8e\u6cbb\u7597Crohn\u75c5\u7684MSCs\u7684potency\u8bc4\u4ef7\u6307\u6807\uff0c\u5374\u6ca1\u6709\u53d1\u73b0\u4e0e\u5176\u7528\u4e8e\u6cbb\u7597\u9002\u5e94\u75c7\u76f4\u63a5\u76f8\u5173\u7684\u6f5c\u80fd\u8bc4\u4ef7\u6307\u6807\u3002<\/span>\n <\/p>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n
\n
\n
\n
\n
\n
\n <\/section>\n <\/section>\n
\n
\n
\n
\n 04<\/strong><\/span>\n <\/section>\n <\/section>\n
\n
\n \u53cd\u5e94\u751f\u4ea7\u8fc7\u7a0b\u7684\u6307\u6807\uff0c\u5305\u542b\u53cd\u5e94\u4e34\u5e8a\u6cbb\u7597\u6240\u9700\u7684\u7ec6\u80de\u6269\u589e\u6570\u91cf\uff08Cell Expansion: Quantity of desired cells\uff09<\/strong><\/span>\n <\/section>\n
\n
\n \u7528\u4e8e\u5224\u65ad\u4e34\u5e8a\u6cbb\u7597\u7684\u76ee\u6807\u7ec6\u80de\u7684\u6570\u91cf\u662f\u5426\u8db3\u591f\u3002\u76ee\u6807\u7ec6\u80de\u7684\u6570\u91cf\u3001\u6d3b\u6027\u548c\u6f5c\u80fd\u76f4\u63a5\u4e0e\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u76f8\u5173\u3002\u540c\u65f6\u4e5f\u5305\u542b\u53cd\u5e94\u751f\u4ea7\u8fc7\u7a0b\u5b89\u5168\u6027\u7684\u6307\u6807\uff0c\u51cf\u5c11\u7ec6\u80de\u7ec8\u4ea7\u54c1\u6742\u8d28\uff0c\u6bd4\u5982\u5185\u6bd2\u7d20\u3001\u652f\u539f\u4f53\u3001\u7ec6\u83cc\u3001\u75c5\u6bd2\u3001\u5fae\u7c92\u3001\u8f85\u6599\u6b8b\u7559\u7b49\u4e0d\u80fd\u8d85\u8fc7\u836f\u5178\u8981\u6c42\u6307\u6807\u7b49\u3002<\/span>\n <\/p>\n <\/section>\n <\/section>\n <\/section>\n
\n
\n
\n 05<\/strong><\/span>\n <\/section>\n <\/section>\n
\n
\n \u50a8\u5b58\u548c\u7a33\u5b9a\u6027\uff08Assessed by potency\uff09<\/strong><\/span>\n <\/section>\n
\n
\n \u4e0e\u4e34\u5e8a\u6cbb\u7597\u9002\u5e94\u75c7\u5339\u914d\u7684\u6f5c\u80fd\u7a33\u5b9a\u6027\u76f8\u5173\uff0cCar-T\u4e3a\u65b0\u9c9c\u4ea7\u54c1\uff0c\u7a33\u5b9a\u6027\u5e94>24\u5c0f\u65f6\uff1bMSCs\u4e3a\u51bb\u5b58\u4ea7\u54c1\uff0c\u7a33\u5b9a\u6027\u5e94>6\u4e2a\u6708\u3002\u4f46\u5982\u679c\u6ca1\u6709\u660e\u786e\u5b9a\u4e49\u6f5c\u80fd\u7684\u6307\u6807\uff0c\u6211\u4eec\u8be5\u5982\u4f55\u8bc4\u4ef7\u7ec6\u80de\u4ea7\u54c1\u7684\u7a33\u5b9a\u6027\uff1f<\/span>\n <\/p>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n
\n \u4ece\u8fd9\u4e9b\u6307\u6807\u7684\u8bc4\u4ef7\u5bf9\u6bd4\u53ef\u4ee5\u770b\u51fa\uff0c\u7ec6\u80de\u6cbb\u7597\u4ea7\u54c1\u7684\u6210\u836f\u6027\uff0c\u4e3b\u8981\u5728\u4e8e\u662f\u5426\u80fd\u4ece\u4e0d\u540c\u7684\u7ef4\u5ea6\u5bf9\u7ec6\u80de\u4ea7\u54c1\u8fdb\u884c\u6e05\u6670\u7684\u5b9a\u4e49\u548c\u8bc4\u4ef7\uff0c\u6307\u5411\u67d0\u4e00\u79cd\u7279\u5b9a\u6807\u8bb0\u7684\u7ec6\u80de\u4ea7\u54c1\u7528\u4e8e\u6cbb\u7597\u4e00\u79cd\u7279\u5b9a\u7684\u4e34\u5e8a\u9002\u5e94\u75c7\u3002<\/strong><\/span>\n <\/section>\n
\n
\n <\/section>\n
\n \u5f88\u663e\u7136\uff0cMSCs\u7684potency\u6307\u6807\u76ee\u524d\u8fd8\u4e0d\u80fd\u50cfCar-T\u90a3\u6837\u5177\u6709\u6e05\u6670\u7684\u754c\u5b9a\u548c\u5b9a\u4e49\uff0c\u76ee\u524d\u56fd\u9645\u4e0a\u4e0d\u540c\u6cd5\u89c4\u4f53\u7cfb\u7684\u76d1\u7ba1\u90e8\u95e8\u5728\u5ba1\u8bc4\u5ba1\u6279MSCs\u4ea7\u54c1\u65f6\uff0c\u91c7\u7528\u7684\u4ecd\u7136\u662fISCT\u5236\u5b9a\u7684\u6700\u4f4e\u6807\u51c6\u2014\u2014\u9274\u5b9a\u6027\u6307\u6807\uff08Identity)\uff0c\u5305\u62ec\u57f9\u517b\u8fc7\u7a0b\u4e2d\u8d34\u58c1\u7279\u5f81\uff0c\u8868\u578b\u6807\u8bb0\uff0c\u4f53\u5916\u5206\u5316\u7279\u5f81\uff0c\u5982\u6210\u9aa8\u3001\u6210\u8102\u3001\u6210\u8f6f\u9aa8\u80fd\u529b\u7b49\u3002\u800c\u8fd9\u53ea\u80fd\u8868\u660e\u751f\u4ea7\u57f9\u517b\u7684\u7ec6\u80de\u662fMSCs\uff0c\u4f46\u5e76\u4e0d\u80fd\u8868\u660e\u751f\u4ea7\u51fa\u7684MSCs\u5fc5\u7136\u80fd\u7528\u4e8e\u6709\u6548\u6cbb\u7597\u67d0\u79cd\u75be\u75c5\u3002<\/span>\n <\/section>\n
\n
\n <\/section>\n
\n \u800c\u5df2\u7ecf\u6210\u836f\u7684Car-T\uff0c\u5177\u6709\u6e05\u6670\u3001\u53ef\u6d4b\u91cf\u7684\uff0c\u80fd\u53cd\u5e94\u5176\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u4e0e\u9274\u5b9a\u6027\u7279\u5f81\u7684\u8fc7\u7a0b\u53c2\u6570\uff0c\u8fd9\u6b63\u662fCar-T\u4e0eMSCs\u53d1\u5c55\u8fdb\u7a0b\u4e2d\u6700\u663e\u8457\u7684\u5dee\u5f02\u3002<\/span>\n <\/section>\n
\n
\n <\/section>\n
\n \u7ec6\u80de\u836f\u7269\u5ba1\u8bc4\u5ba1\u6279\u5173\u6ce8\u70b9\u7684\u76f8\u5e94\u8f6c\u79fb\u3002\u4eceCar-T\u5ba1\u8bc4\u5ba1\u6279\u7684\u8fc7\u7a0b\u6765\u770b\uff0c\u4e0d\u540c\u6cd5\u89c4\u4f53\u7cfb\u7684\u76d1\u7ba1\u90e8\u95e8\u5728\u5ba1\u8bc4\u5ba1\u6279\u7ec6\u80de\u4ea7\u54c1\u65f6\u8fdb\u884c\u4e86\u9002\u5e94\u6027\u7684\u6743\u91cd\u8c03\u6574\u3002\u4e00\u822c\u836f\u7269\u7684\u5ba1\u8bc4\u5ba1\u6279\u6743\u91cd\uff0c80%\u662f\u653e\u5728\u4e34\u5e8a\u7597\u6548\u6570\u636e\u8bc4\u4ef7\uff0c\u53ea\u670920%\u7684\u6743\u91cd\u53bb\u770b\u836f\u7269\u7684CMC\uff08\u5316\u5b66\u3001\u751f\u4ea7\u548c\u8d28\u63a7\uff09\uff0c\u4f46\u6d3b\u7ec6\u80de\u4ea7\u54c1\u7684\u8bc4\u4ef7\u6743\u91cd\u5374\u5b8c\u5168\u98a0\u5012\u3002\u56e0\u4e3a\u6d3b\u7ec6\u80de\u7684\u5929\u7136\u7279\u5f81\uff0c\u662f\u5176\u6f5c\u80fd\u4f1a\u53d7\u5230\u5fae\u73af\u5883\u6216\u57f9\u517b\u6761\u4ef6\u7684\u8bf1\u5bfc\u548c\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u751f\u4ea7\u8fc7\u7a0b\u53c2\u6570\u7684\u53ef\u6d4b\u91cf\u548c\u53ef\u56de\u6eaf\u4e0e\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u548c\u6cbb\u7597\u5b89\u5168\u6027\u606f\u606f\u76f8\u5173\u3002<\/span>\n <\/section>\n
\n
\n <\/section>\n
\n \u6211\u4eec\u518d\u56de\u5230\u672c\u6587\u7684\u4e3b\u9898\uff0c\u76ee\u524d\u56fd\u5bb6\u536b\u5065\u59d4\u6279\u590d\u540c\u610f\u5907\u6848\u768474\u9879MSCs\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u4ea7\u751f\u7684\u7814\u7a76\u6570\u636e\uff0c\u80fd\u5426\u4f5c\u4e3a\u8bc1\u636e\u652f\u6301MSCs\u836f\u7269\u7684\u5ba1\u8bc4\u5ba1\u6279\uff1f<\/span>\n <\/section>\n
\n
\n $\"\u56fe\u7247\"$ \n <\/section>\n <\/section>\n
\n \u9996\u5148\uff0c\u6211\u4eec\u9700\u8981\u5c06\u7528\u4e8e\u4e34\u5e8a\u7814\u7a76\u7684MSCs\u8fdb\u884c\u5b9a\u4e49\u548c\u754c\u5b9a\uff0c\u5c31\u662f\u8981\u660e\u786e\u7684\u6307\u51fa\u4e0d\u540c\u7ec4\u7ec7\u6765\u6e90\u7684MSCs\u5e94\u5f53\u9488\u5bf9\u6027\u5730\u7528\u4e8e\u6cbb\u7597\u54ea\u4e9b\u4e0d\u540c\u7c7b\u578b\u7684\u75be\u75c5\uff0c\u4e14\u5177\u5907\u8fd9\u4e9b\u529f\u80fd\u7684\u7ec6\u80de\u5e94\u5f53\u6709\u54ea\u4e9b\u7279\u5f81\u3002\u6bd4\u5982\uff0c\u6cbb\u7597\u7f3a\u8840\u6027\u75be\u75c5\u7684MSCs\u4e0e\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684MSCs\u662f\u4e0d\u662f\u8981\u6709\u4e0d\u540c\u7684\u57f9\u517b\u4f53\u7cfb\u548c\u9274\u5b9a\u6807\u8bb0\uff1f<\/span>\n <\/section>\n
\n
\n <\/section>\n
\n \u76ee\u524d\uff0c\u667a\u80fd\u5316\u3001\u6570\u5b57\u5316\u6b63\u63a8\u52a8\u7740\u5404\u884c\u5404\u4e1a\u53d8\u9769\u7684\u53d1\u751f\uff0c\u6db5\u76d6\u4ece\u6d41\u7a0b\u4f18\u5316\u5230\u590d\u6742\u95ee\u9898\u7684\u89e3\u51b3\uff0c\u4f46\u4e0e\u4eba\u6c11\u751f\u547d\u5065\u5eb7\u606f\u606f\u76f8\u5173\u7684\u7ec6\u80de\u836f\u7269\u7684\u751f\u4ea7\u5374\u8fd8\u5904\u4e8e\u8d39\u65f6\u8d39\u529b\u7684\u201c\u624b\u5de5\u201d\u9636\u6bb5\uff0c\u8fd8\u5904\u4e8e\u751f\u4ea7\u8fc7\u7a0b\u8bb0\u5f55\u7684\u201c\u624b\u5199\u201d\u72b6\u6001\u3002<\/span>\n <\/section>\n
\n
\n <\/section>\n
\n \u81ea\u52a8\u5316\u3001\u6570\u5b57\u5316\u548c\u667a\u80fd\u5316\u80fd\u63d0\u4f9b\u7ec8\u6781\u89e3\u51b3\u65b9\u6848\uff0c\u4e0d\u4ec5\u80fd\u4e3a\u4e34\u5e8a\u7814\u7a76\u673a\u6784\u63d0\u4f9b\u6807\u51c6\u7684\u7ec6\u80de\u4ea7\u54c1\uff0c\u540c\u65f6\u80fd\u4fc3\u4f7f\u5907\u6848\u9879\u76ee\u7684\u7814\u7a76\u7ed3\u679c\u6210\u4e3a\u771f\u5b9e\u4e16\u754c\u8bc1\u636e\uff0c\u652f\u6301\u7ec6\u80de\u836f\u7269\u5ba1\u8bc4\u5ba1\u6279\u3002<\/span><\/strong><\/span>\n <\/section>\n
\n
\n <\/section>\n
\n
\n
\n
\n
\n
\n
\n 1<\/strong><\/span>\n <\/section>\n <\/section>\n
\n
\n \u5c06\u4e0d\u540c\u72b6\u6001\u7684MSCs\u7684\u7269\u7406\u7279\u5f81\u4e88\u4ee5\u6d4b\u91cf\u8bb0\u5f55\uff0c\u5e76\u5173\u8054\u5176\u8868\u578b\u7684\u8868\u8fbe\uff0c\u5f62\u6210\u751f\u4ea7\u8fc7\u7a0b\u8fde\u7eed\u76d1\u6d4b\u6307\u6807\u3002\u8d5b\u52a8\u667a\u9020\u901a\u8fc7\u8fd0\u7528\u7279\u5b9a\u7684\u7b97\u6cd5\u5728\u5176\u7269\u7406\u5b66\u5f62\u6001\u7279\u5f81\u4e0e\u7ec6\u80de\u8868\u9762\u6807\u8bb0\u7269\u4e3a\u4e3b\u7684\u751f\u7269\u5b66\u529f\u80fd\u8868\u8fbe\u7ed3\u679c\u4e2d\u642d\u5efa\u6865\u6881\uff0c\u63a2\u5bfb\u4e24\u8005\u4e4b\u95f4\u6f5c\u5728\u7684\u76f8\u5173\u6027\u3002\u7814\u7a76\u6210\u679c\u201cSegmentation Detection and Tracking of Stem Cell Image Based on Digital Twins\u201d\u53d1\u8868\u4e8e\u201cImage and Vision Computing\u201d\u6742\u5fd7\u4e0a\u3002<\/span>\n <\/section>\n
\n
\n <\/section>\n
\n \u7528\u4eba\u5de5\u667a\u80fd\u4e0e\u56fe\u50cf\u8bc6\u522b\uff0c\u5efa\u7acb\u4e00\u79cd\u53ef\u4ee5\u9002\u7528\u4e8e\u5c01\u95ed\u5f0f\u3001\u81ea\u52a8\u5316\u8fde\u7eed\u751f\u4ea7\u7684\u7ec6\u80de\u751f\u957f\u76d1\u6d4b\u65b9\u6cd5\uff0c\u5b9e\u73b0\u7ec6\u80de\u5f62\u6001\u7279\u5f81\u8868\u8fbe\u7684\u5173\u952e\u8d28\u91cf\u5c5e\u6027\u3002<\/span>\n <\/section>\n
\n
\n <\/section>\n
\n \u7ecf\u7814\u7a76\u53d1\u73b0\uff0c\u7ec6\u80de\u57f9\u517b\u8fc7\u7a0b\u4e2d\uff0c\u6700\u4f73\u751f\u957f\u72b6\u6001\u7684MSCs\u5448\u73b0\u201c\u7ec6\u957f\u68ad\u5f62\u201d\uff0c\u5e76\u901a\u8fc7\u53ef\u6d4b\u91cf\u7684\u201c\u9ad8\u957f\u5bbd\u6bd4\u4e0e\u4f4e\u6838\u8d28\u6bd4\u201d\u7684\u7269\u7406\u7279\u5f81\u6570\u636e\u4ee5\u91cf\u5316\u524d\u8ff0\u7684\u7ec6\u80de\u5f62\u6001\u2014\u2014\u4ec0\u4e48\u6837\u7684\u7ec6\u957f\u68ad\u5f62\u5c31\u662f\u597d\u7684\u3002\u901a\u8fc7\u751f\u7269\u5b66\u529f\u80fd\u6821\u9a8c\u53d1\u73b0\uff0c\u8be5\u7269\u7406\u5f62\u6001\u4e0b\u7684MSCs\u5728CD105\u3001STRO-1\u3001CD29\u3001CD44\u7684\u6d41\u5f0f\u6d4b\u5b9a\u7ed3\u679c\u4e2d\u5448\u73b0\u4e3a\u9ad8\u8868\u8fbe\u3002\u800c\u8870\u8001\u72b6\u6001\u7684MSCs\u4ece\u5f62\u6001\u4e0a\u5c31\u201c\u957f\u201d\u5f97\u80a5\u5927\u800c\u7a81\u51fa\uff0c\u5176\u7269\u7406\u7279\u5f81\u4e3a\u201c\u4f4e\u957f\u5bbd\u6bd4\u4e0e\u9ad8\u6838\u8d28\u6bd4\u201d\uff0c\u540c\u65f6\u6d4b\u5f97\u4e0a\u8ff0\u8868\u9762\u6807\u8bb0\u7269\uff08CD105\u3001STRO-1\u3001CD29\u3001CD44\uff09\u8868\u8fbe\u91cf\u8f83\u4f4e\u3002 <\/span>\n <\/section>\n
\n
\n <\/section>\n
\n \u5bf9\u6bd4\u5f53\u524d\u56fd\u9645\u901a\u7528\u7684MSCs\u6700\u4f4e\u6807\u51c6\uff0c\u624b\u5de5\u751f\u4ea7\u7684MSCs\u4ec5\u4ec5\u53ea\u80fd\u8bc1\u660e\u6536\u83b7\u7684\u7ec6\u80de\u7c7b\u578b\u662f\u5426\u6b63\u786e\uff0c\u4f46\u8fd9\u4e9b\u7ec6\u80de\u5904\u4e8e\u4f55\u79cd\u751f\u957f\u72b6\u6001\u5374\u65e0\u6cd5\u9274\u522b\uff0c\u4e5f\u56e0\u6b64\u5bfc\u81f4\u4e34\u5e8a\u6cbb\u7597\u6548\u679c\u7684\u4e0d\u7a33\u5b9a\u3002<\/span>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n
\n
\n
\n
\n
\n
\n 2<\/strong><\/span>\n <\/section>\n <\/section>\n
\n
\n \u667a\u80fd\u751f\u4ea7\u5185\u5d4c\u7684\u5728\u7ebf\u8fde\u7eed\u76d1\u6d4b\uff0c\u80fd\u901a\u8fc7\u751f\u957f\u8fc7\u7a0b\u4e2d\u7684\u7ec6\u80de\u751f\u957f\u72b6\u6001\u7684\u76d1\u6d4b\u8bc6\u522b\u5e76\u6536\u83b7\u201c\u6700\u4f73\u72b6\u6001\u201d\u7684MSCs\uff0c\u5e76\u4f9d\u636e\u5bf9\u751f\u4ea7\u8fc7\u7a0b\u4e2d\u7ec6\u80de\u7684\u8fde\u7eed\u5728\u7ebf\u72b6\u6001\u76d1\u6d4b\u56de\u6eaf\u5176\u5173\u952e\u7269\u6599\u8d28\u91cf\uff0c\u5b9a\u4e49\u9002\u914d\u6700\u4f73\u72b6\u6001\u7ec6\u80de\u6240\u9700\u7684\u6700\u4f73\u7ec6\u80de\u79cd\u690d\u5bc6\u5ea6\uff0c\u5173\u952e\u7269\u6599\u7684\u6700\u4f73\u65f6\u6548\u7b49\u8fc7\u7a0b\u53c2\u6570\u3002<\/span>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n
\n
\n
\n
\n
\n
\n 3<\/strong><\/span>\n <\/section>\n <\/section>\n
\n
\n \u7ec6\u80de\u667a\u9020\u5de5\u4e1a\u8f6f\u4ef6\u6784\u5efa\u7684\u7528\u4e8e\u4e34\u5e8a\u7814\u7a76\u7ec6\u80de\u4ea7\u54c1\u7684\u5168\u6d41\u7a0b\u751f\u4ea7\u6570\u5b57\u5b6a\u751f\u5e73\u53f0\uff0c\u5b9e\u65f6\u201c\u518d\u73b0\u201d\u7ec6\u80de\u4ea7\u54c1\u7684\u751f\u4ea7\u8fc7\u7a0b\u548c\u6db5\u76d6\u201c\u4eba\u3001\u673a\u3001\u6599\u3001\u6cd5\u3001\u73af\u201d\u7684\u8d28\u91cf\u7ba1\u7406\u4f53\u7cfb\uff0c\u5c06\u4fc3\u8fdb\u5f53\u524d\u4e34\u5e8a\u7814\u7a76\u9879\u76ee\u5907\u6848\u7531\u201c\u51c6\u5907\u6750\u6599\u4f9b\u5ba1\u67e5\u201d\u8f6c\u5411\u201c\u76f4\u63a5\u5f00\u653e\u7aef\u53e3\u5b9e\u65f6\u5728\u7ebf\u89c2\u770b\u201d\uff0c\u4e3a\u7814\u7a76\u9879\u76ee\u5907\u6848\u7533\u62a5\u65b9\u4e0e\u76d1\u7ba1\u90e8\u95e8\u5ba1\u67e5\u7684\u5de5\u4f5c\u91cf\u5e26\u6765\u201c\u53cc\u51cf\u201d\uff0c\u5e76\u5c3d\u53ef\u80fd\u89c4\u907f\u201c\u51c6\u5907\u7684\u8d44\u6599\u4e0e\u5b9e\u9645\u4e0d\u7b26\u201d\u7684\u60c5\u51b5\u7684\u53d1\u751f\u3002<\/span>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n <\/section>\n
\n
\n
\n
\n
\n
\n 4<\/strong><\/span>\n <\/section>\n <\/section>\n
\n
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